Dungrawala Lab

PHIP variants associated with Chung-Jansen syndrome disrupt replication fork stability and genome integrity

Neysha Tirado-Class, Caitlin Hathaway, Wendy K. Chung and Huzefa Dungrawala

Cold Spring Harbor Molecular Case Studies 2022 Jul 21

DCAF14 promotes stalled fork stability to maintain genome integrity

Arik Townsend, Gabriella Lora, Justin Engel, Neysha Tirado-Class, Huzefa Dungrawala

Cell Rep 2021 Jan 26;34(4):108669. doi: 10.1016/j.celrep.2020.108669.

Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators

Wessel SR, Mohni KN, Luzwick JW, Dungrawala H, Cortez D

Cell Rep. 2019 Sep 24;28(13):3497-3509.e4. doi: 10.1016/j.celrep.2019.08.051

RADX Modulates RAD51 Activity to Control Replication Fork Protection.

Bhat KP, Krishnamoorthy A, Dungrawala H, Garcin EB, Modesti M, Cortez D.

Cell Rep. 2018 Jul 17;24(3):538-545. doi: 10.1016/j.celrep.2018.06.061.

Yeast lifespan variation correlates with cell growth and SIR2 expression.

Smith JT, White JW, Dungrawala H, Hua H, Schneider BL.

PLoS One. 2018 Jul 6;13(7):e0200275. doi: 10.1371/journal.pone.0200275. eCollection 2018.

RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.

Dungrawala H, Bhat KP, Le Meur R, Chazin WJ, Ding X, Sharan SK, Wessel SR, Sathe AA, Zhao R, Cortez D.

Mol Cell. 2017 Aug 3;67(3):374-386.e5. doi: 10.1016/j.molcel.2017.06.023. Epub 2017 Jul 20.

Synchronization of Yeast.

Smith J, Manukyan A, Hua H, Dungrawala H, Schneider BL.

Methods Mol Biol. 2017;1524:215-242.

ETAA1 acts at stalled replication forks to maintain genome integrity.

Bass TE, Luzwick JW, Kavanaugh G, Carroll C, Dungrawala H, Glick GG, Feldkamp MD, Putney R, Chazin WJ, Cortez D.

Nat Cell Biol. 2016 Nov;18(11):1185-1195. doi: 10.1038/ncb3415. Epub 2016 Oct 10.

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.

Dungrawala H, Rose KL, Bhat KP, Mohni KN, Glick GG, Couch FB, Cortez D.

Mol Cell. 2015 Sep 17;59(6):998-1010. doi: 10.1016/j.molcel.2015.07.030. Epub 2015 Sep 10.

Purification of proteins on newly synthesized DNA using iPOND.

Dungrawala H, Cortez D.

Methods Mol Biol. 2015;1228:123-31. doi: 10.1007/978-1-4939-1680-1_10.

Identification of proteins at active, stalled, and collapsed replication forks using isolation of proteins on nascent DNA (iPOND) coupled with mass spectrometry.

Sirbu BM, McDonald WH, Dungrawala H, Badu-Nkansah A, Kavanaugh GM, Chen Y, Tabb DL, Cortez D

J Biol Chem. 2013 Nov 1;288(44):31458-67. doi: 10.1074/jbc.M113.511337. Epub 2013 Sep 18.

Identification of new cell size control genes in S. cerevisiae.

Dungrawala H, Hua H, Wright J, Abraham L, Kasemsri T, McDowell A, Stilwell J, Schneider BL.

Cell Div. 2012 Dec 12;7(1):24. doi: 10.1186/1747-1028-7-24.

A growing role for hypertrophy in senescence.

Wright J, Dungrawala H, Bright RK, Schneider BL.

FEMS Yeast Res. 2013 Feb;13(1):2-6. doi: 10.1111/1567-1364.12015. Epub 2012 Nov 23.

FASTA barcodes: a simple method for the identification of yeast ORF deletions.

McMahon KW, Manukyan A, Dungrawala H, Montgomery M, Nordstrom B, Wright J, Abraham L, Schneider BL.

Yeast. 2011 Sep;28(9):661-71. doi: 10.1002/yea.1894. Epub 2011 Aug 1.

Synchronization of yeast.

Manukyan A, Abraham L, Dungrawala H, Schneider BL.

Methods Mol Biol. 2011;761:173-200. doi: 10.1007/978-1-61779-182-6_12.

Cell size and growth rate are major determinants of replicative lifespan.

Yang J, Dungrawala H, Hua H, Manukyan A, Abraham L, Lane W, Mead H, Wright J, Schneider BL.

Cell Cycle. 2011 Jan 1;10(1):144-55. doi: 10.4161/cc.10.1.14455.

Gene regulation: global transcription rates scale with size.

Dungrawala H, Manukyan A, Schneider BL.

Curr Biol. 2010 Nov 23;20(22):R979-81. doi: 10.1016/j.cub.2010.09.064.